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Allergic Reactions to Gloves: Causes and Solution
by Donald F. Groce, Best Manufacturing Company

Extraneous Causes
Many times contact dermatitis is attributed to gloves when in fact, the causative agent is from another source. The most notable is a change in soap or detergents. One of the most common causes of irritant contact dermatitis is a change in soaps or incomplete rinsing of the hands after washing. Many times switching to a mild pH-neutral cleanser eradicates the problem of irritant contact dermatitis. Skin cleansers designed for and labeled as “heavy-duty cleansers” or “waterless hand cleaners” can have more irritating ingredients including solvents and abrasives such as silica or wood particles. Many times incomplete rinsing of the cleansers from the skin can cause irritant contact dermatitis. Occlusion of the hand by wearing a glove on top of the residual irritants can aggravate the condition.

Exposure to Chemicals
Thin-gauge disposable gloves are not designed for heavy exposure to chemicals. There are some chemicals that can be safely handled while wearing thin-gauge disposable gloves. However, for heavy exposure to dangerous organic solvents or highly corrosive chemicals, chemical resistant gloves are recommended. Sometimes the fumes of a chemical can permeate a disposable glove and be held next to the skin and cause an irritant contact dermatitis or an allergic sensitization reaction.

Glove Reactions
Most allergic reactions to gloves are seen with unsupported gloves. Most of these reactions are reported in the health care settings where gloves are worn most of the time and are changed frequently and hands are washed whenever gloves are changed. There are at least three causes of contact and allergic contact dermatitis (Type IV Delayed Contact Urticaria). Natural rubber proteins, glove powder or rubber accelerators can cause irritant or allergic contact dermatitis. Common rubber accelerators include: carbamates, thiurams and mercaptobenzothiazole (MBT). These ingredients are present in almost every elastomeric glove made.

To determine which ingredient is causing the contact dermatitis, we recommend the following screening protocol:

Allergy Screening

1. Natural Rubber Proteins
If you know that you are indeed allergic to natural rubber proteins, change to a synthetic alternative glove such as nitrile or neoprene or PVC gloves. For medical gloves, Best® N-DEX® Non- Latex Gloves are an excellent alternative. None of the synthetic polymer gloves contain natural rubber proteins. Hypoallergenicity testing using the modified Draize test for chemical sensitivity resulted in no test subjects having any kind of reaction.

2. Glove Powder
Many people believe that they are allergic to glove powder. Most glove powder used to manufacture gloves is food-grade cornstarch used in foods and is not an allergy causing material. However, glove powder has been implicated in cases of latex allergy because it can serve a carrier of the natural rubber latex protein. The latex protein laden cornstarch can be inhaled. So, in latex gloves, a person can react to the latex-containing cornstarch, but in synthetics such as N-DEX nitrile gloves, the cornstarch does not contain latex and will not cause allergic reactions. If a person is still having a rash after changing to Best® N-DEX® Non-Latex Medical Gloves, they could be experiencing irritant contact dermatitis from the corn starch powder. This type of reaction is not considered an allergic response. If so, we recommend changing to Best® N-DEX® Non-Latex “Powder Free” Medical Gloves. These styles have the suffix PF in the SKU.

3. Rubber Accelerators
If a person is still having an allergic reaction even after changing to the Best® N-DEX® Non-Latex “Powder Free” Medical Glove, they could be allergic to the rubber accelerator MBT. The level of MBT in Best® N-DEX® Non-Latex Medical Gloves is less than half the extractable level determined by Johns Hopkins, Cleveland Clinic and the FDA to trigger an allergic contact dermatitis in MBT-sensitized patients. This accelerator is a necessary ingredient and is the only accelerator used in N-DEX gloves. There are no carbamates or thiurams used in N-DEX gloves. These other accelerators are known to cause allergic reactions in more individuals than MBT. Sometimes a patient is allergic to all of the rubber accelerators. In that case, they should be advised to try a vinyl disposable glove or one that is free of accelerators.

Copyright © 2004 Best Glove. All rights reserved. This information is provided “as is” and is not to be considered a warranty of product performance or as an authoritative informational page. Due to the diverse field conditions and other variables which can affect a product’s performance, Calolympic Safety disclaims all warranties (expressed and implied) as to any product’s performance or any information provided.


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